CoQ10 Minimizes Oxidative Stress Associated with Strenuous Exercise

Coenzyme Q10 (CoQ10) was shown in a recent study to reduce the oxidative stress associated with exercise. CoQ10 is a potent endogenous fat-soluble antioxidant important in the synthesis of cellular energy. Strenuous exercise is associated with the production of free radicals and pro-inflammatory mediators, which can result in suboptimal tissue health.

The subjects received either a CoQ10 oral supplement or a placebo. The subjects completed a physical test consisting of a 50 km constant run including several degrees of high effort in permanent climbing. Assessments of the subjects included levels of markers of oxidative stress, antioxidants and pro-inflammatory mediators.

The study showed that exercise resulted in an increase in several markers of oxidative stress and pro-inflammatory mediators including tumor necrosis factor (TNF)-a, interleukin (IL)-6, 8-hydroxy-2¢-deoxyguanosine (a product of DNA oxidation), and isoprostane, which is formed from free radical-catalyzed reactions with fatty acids.

CoQ10 supplementation resulted in reduced markers of oxidative stress such as membrane hydroperoxides, 8-hydroxy-2¢-deoxyguanosine and isoprostanes generation, while increasing the antioxidant enzyme catalase and total antioxidant status. The researchers state that these changes with CoQ10 supplementation support the maintenance of the integrity of the cells. Furthermore, CoQ10 supplementation reduced the production of the muscle breakdown product, creatinine.

The researchers stated that CoQ10 supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent suboptimal muscle tissue health.

Reference:

Diaz-Castro J, Guisado R, Kajarabille N, Garcia C, Guisado IM, de Teresa C, Ochoa JJ. Coenzyme Q10 supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise. Eur J Nutr. 2011 Oct 12. Published Online Ahead of Print.