Dear Dr. Dean

The item description for AGEBlock both in the VRP catalog and on the bottle does not indicate whether to take this supplement with meals or on an empty stomach.

From past usage I recognize that one of the ingredients to AGEBlock Carnosine should be taken on an empty stomach. Does the same hold true for AGEBlock?

Thanks

JS

Dear Dr. Dean

I have read the generalized information about aging and the recommendations which are not too specific about antioxidants etc. I would like a specific regimen for a 78-year-old male who eats a balanced Ayurvedic diet is in general good health except for atrial fibrillation (2 mg/day Coumadin). Although I have BPH it is not a problem as long as I eat properly. I have no limit on the number of capsules I can take daily but am concerned with cost.

My understanding of the general recommendations:

* Extend Core 2 caps
* Essential Minerals 3 caps
* Phytonutrients ???
* Antioxidants ???
* Hormones ???
* Hypothalamic Sensitizers ???
* Cellular Bioenergetics ???

J. Doering

Dear Dr. Dean

I am having difficulty with the amino acid supplements. It is my understanding that they must be taken on an empty stomach and separate from each other. So on an empty stomach I take L- Proline and 1 hour later I
take N-Acetyl-L-Cysteine . I also take L-Carnitine Taurine Glutamine Carnosine Arginine and L-Tyrosine and at bed time I take 5-HTP and
Melatonin together. This is a very difficult schedule to maintain. Are any of these supplements that I can take at the same time and still have them be effective?

Sincerely
T. Birchall

Hi Dr. Dean

Im looking for a source of aminoguanidine. It is supposed to stop protein/glucose crosslinking. Do you have any or know where I can get some?

James K.

Dear Dr. Dean:

What is the most powerful anti-aging antioxidant.

George

Dear Dr. Dean:

I am a 56-year-old healthy female. No real health issues except I want to remain that way. Good skin no wrinkles good hair etc.

What is the very best product to stay this way? I did have juvenile rheumatoid arthritis few symptoms now but I do have some loss of libido... Got the answer?

My husband has severe health issues due to failed back surgery syndrome and I will address this with you on a consultation.

Thanks for your help

LI

Dear Dr. Dean

Is there anything new with regard to BHT addition to cooking oils for peroxidation protection? I have heard off and on over the years that BHT may act as a carcinogen under some conditions? If so what are those conditions?

We have been adding it to our polysaturated fat cooking oils -- but I wonder if this is the right thing to do now? We do take a reasonable amount of antioxidants on a daily basis.

What are your thoughts?

Regards
Jeff

Dear Dr. Dean:

Hormone replacement...testosterone thyroid HGH in order to maintain reproducing levels of a 30 year old.

Whats your take and do you subscribe to this therapy?

I am a CP provider.

Thanks!!

Dr. HW

Dear Dr. Dean:

I have listened to the tape of Dr. Rossellinis talk at the 2001 Monaco Anti-Aging Conference. I would like to contact his institute and find out how to go about getting the tests he suggests for autoimmune disorders. I have found the name of the Institute in Italy with which he is affiliated but have no address or phone #. Can you supply any information?

BB

Dear Dr. Dean:

I just saw the following new study: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12969875&dopt=Abstract. Doesn't this suggest that the benefits of calorie restriction may predominantly result from reduced insulin levels and that, accordingly, a diet such as Atkins, which reduces insulin levels by controlling carbohydrate consumption, seems a clear best dietary option?

SB

Dear Dr. Dean:

I recently listened to the talk on carnosine given at the 2001 Anti-aging Conference. It renewed my interest in this product as a supplement to goats rue the anti-crosslinking substance in your GluControl and AGEBlock products. It sounds like carnosine could reverse crosslinking while goats rue primarily prevents new crosslinking. I remember reading one of your answers to a Dear Dr. question where you were not in favor of carnosine supplementation. I cant find this response (there is no category for carnosine itself so Im not sure what topic I was looking at when I saw it). It seemed you had some reservations but I dont remember the details. Can you clear this up for me?

BB

Dear Dr. Dean,

I have been following the articles on anti-aging with interest. Within my
current supplement program I am taking DHEA, CoQ10 and Melatonin. All of this per my doctor’s instruction.

In the October newsletter, you discussed Carnosine. My question is, should this be added to my program? For your information, I am a 70-year- old male in fairly good health, although I have been diagnosed with liver disease.

Sincerely — Mr. M.

Dear Dr. Dean:

I ordered the 2001 Monaco anti-aging series and want to take carnosine.

I am concerned about the possibility of this product causing lipofuscin as mentioned on the Internet. The internet says to take Acetyl N-carnitine (too expensive) or DMAE.

VRPs DMAE has riboflavin in it which is in my multivitamin at high enough amounts so I could try your powder form.

My further concerns are that DMAE has a lot of possible side-effects so I would like to take the smallest functional dose. Also DMAE promotes
the formation of acetylcholine which Dr. M. Rossellini says is one of the immuno-stimulants which would not be good for my osteoporosis.

I woke up one morning in Hawaii 15 years ago with my arms covered in big brown blotches so I dont want any more. Ive ordered and received the carnosine from VRP and am just waiting for answers to my concerns before I start this program. Thank you for any help. I enjoy the VRP newsletter.

Loretta

Dear Dr. Dean:

I have read conflicting reports on the correct dose of carnosine to prevent glycation. Some sources say 500mg 2-3 times a day is required and others say 50mg 2-3 times a day is adequate. When I take the higher dose I get a headache but dont seem to have a problem with the lower dose. Am I getting any benefits taking 50mg 2-3 times a day. Please advise.

Thank You
AM

Dear Dr. Dean:

I am a 75-year old male. I have been taking supplements for thirty years and have been a customer of VRP for over fifteen years. I have been jogging about four days per week and meditating daily. I have recommended your organization with pleasure to friends around the country. I am a high-tech entrepreneur and have a reasonably demanding business life with significant stress. In general I believe my health is very good. But now I am noticing a problem which brings me to ask your help.

My short-term memory is declining noticeably. For example if I try to remember all the details of a complicated conversation I had yesterday I find it harder to bring those back. Also if I need to make a decision which involves balancing a variety of factors I find it takes me significantly longer than it used to. I think this may just be a normal aging process. But I would very much appreciate your giving me a recommendation either of particular supplements to take to counteract or reverse this and/or a book or other publication which may cover reasonably current thoughts on this same subject. This might include but not be limited to things available from VRP or IAS.

Thank you very much for yor help in this matter.

JD

Dear Dr. Dean:

I am a customer of both IAS and VRP (for 10 years). I am 46 years old in excellent health but at times have a bit of Dyslexia and even more Attention Deficit Disorder. I played professional tennis until I was 30 but currently sit at a desk most of the day focusing and concentrating
intently on my stock trading business. Smart Nutrients and Drugs and Longevity interest me a great deal.

Could you please comment on the use of Deprenyl (just ordered it never tried) with products like Blast Off (with phenylalanine -- which I use about once a day). Also DMAE with Deprenyl. I am particularly concerned about the MAO inhibitor issues and contraindications.

And could you please comment on the combining of the following:

Piracetam (I just started taking 600 mg to 1200 mg/day)
Oxiracetam (just ordered)
Pramiracetam (just ordered)
Centrophenoxine (just ordered)
Adrafinil (which I have tried presently take once or twice a month)

My VRP products:

Optimum 6
Green Tea
Extension IQ
Extension Vision
ALC
Phosphatidyl Serine
PABA
Adaptaphase One
Performance Plus

Additional Products:

DMAE
Glucosamine
Saw Palmetto
Soy Isoflavones

Thanks for any suggestions you might have.

Sincerely Sean K.

Dear Dr. Dean:

The latest anti-aging protocol of 500-1500 mg of Metformin daily I find very interesting. However I am reluctant to take so much of a prescription drug. At age 60 and in excellent health I would like to keep my health. Has anyone looked into using the various herbals that operate in a similiar way to metformin (Glucosol gymnema sylvestre etc)? Possibly with a lesser amount of the metformin?
JD

Dear Dr. Dean:

Re-studying your November 2004 piece about AGE's and cross-linking, I could not determine what combination of aminoguanidine, goat's rue extract, P5P, benfotiamine should apply.  When the VRP new catalog came I thought I would find the answer.  I see two products, AGEBlock™ and benfotiamine. 

The catalog doesn't say which is best, if both are needed, if the other items on page 30 should be added. Can you help?  Should Metformin also be considered?

In addition, I'm told that taking Lithium Orotate lowers thyroid function.  Might two Lithium Orotate capsules per day require an adjustment, such as beginning thyroid supplementation or increasing the dose of thyroid supplementation used?
 
CH

Dear Dr Dean

Thank you for bringing Dr Franks wonderful work with RNA back to attention. I still have his books (the 2nd one is a cookbook) that I purchased in the 70s and wouldnt part with them.

Im writing because you mention his untimely death at the age of 57 as being due to his diabetes. Ive long been under the impression that his death was actually due to being struck by a car while walking across the street in downtown Manhattan.

Id swear I remember reading this in the popular health magazines of the 70s/80s such as Prevention or perhaps Lets Live.

If this is correct it would be a shame for people to believe that it was the diabetes that killed him. Is there any way of verifying the cause of his death?

Sincerely

SRM

Dear VRP

I am a 52-year-old white male (6 1 185 lbs 15% body fat). My health is excellent and I workout 3 days a week at the gym for 2 1/2 hours each day with 40 minutes of stretching at home before the gym. Also I exercise at home on a stationary bike with no resistance 25 minutes per day 3 days a week with 20 minutes of stretching each (at home) day.

I live in the most polluted part of Los Angeles county; the San Gabriel Valley. I use hepa air purifiers 1/2 per day at home and an air purifier on low in my bedroom while I sleep (with the window opened 1 1/2 inches at
night).

My question is: How do I use EnteraKlenz if I have never detoxified in my life and am doing it for life-extension purposes? The instructions are unclear to me and I may need more than the recommended doses for how big I am physically. The serving size on the label is 16 grams - yet the recommended dose is 10 grams. Which dose do I take?

Customer Service said to take it 2-3 times per week for one month; than once a month for the rest of my life. For my once a month maintenance dose is that once a day for two consecutive days each month for life extension or is it once per day each month?

Also can I continue to refrigerate EnteraKlenz after opening it? Please be precise and detailed in your instructions. Thank you for your help.

Kurt

Dear Dr. Dean:

In an article in VR News you discussed one of VRPs products and stated it would be suitable as a replacement for (Gero Vita GH3) Could you please tell me which product you were refering to?
PL

Dear Dr Dean,

I am writing to you having been recommended to do so by Dr Ralph Cinque, who thinks you may be more qualified to answer a question I put to him regarding Gerovital H3 and Centrophenoxine.

I have been taking Gerovital H3 for a while with excellent results, and have recently heard about Centrophenoxine as an anti-aging substance. I know that GH3 breaks down in the body into two substances (PABA and DEAE) and that the main byproduct of Centrophenoxine is DMAE, which apparently is very similar to DEAE. The question I put to Dr Cinque was whether there was
any point in taking GH3 and Centrophenoxine together for this reason, and whether there might be any sort of negative reaction to doing so: e.g too much acetylcholine release.

I would not give up GH3 but wondered what, if any, the differences were between DEAE and DMAE and whether Centrophenoxine would be a useful (or useless) addition. I would be very grateful
for any comments that you might have.

Regards,
Mr. W

Im looking for the most effective GH releaser. Ive tried Performance Plus which seems to work well especially in higher doses. ProHGH seem to work ok as well. Ive also seen KeyTropin but have never tried it. Is there any anecdotal evidence from your customers as to which is the most effective? Thanks

Dear Dr. Dean

Is a product like Gerovital GH-3 more effective when injected or should it be used on a rotational basis ie. used orally for a period of time and then injected for a period of time? Is the product Aslavital available anywhere?

Thank you.

Dear Dr. Dean

How much GluControl would be required to achieve the result obtained from taking a 500 mg tablet of Metformin?

Thanks
Charles H.

Dear Dr. Dean:

In your May newsletter you made mention of the need for hormone testing and the taking of supplemental hormones if needed.

Normally of approximately 70 hormones in the body only about seven hormones are tested and supplements provided if needed.

My question is: are hormones similar to B vitamins in that supplementing some may cause a shortage or imbalance of others? In other words if I have a low level of two or three hormones and start taking supplements for these two or three hormones will it cause a shortage or imbalance in the remaining hormones?

Thanks

S. Lester

I recently heard an advertisment for a product called hyaluronic acid (HA). Supposedly it is a derived from some foods and is a component of the bodys collagen that can prevent the gradual deterioration that occurs with age. Thus in theory many degenerative diseases can be prevented or at least delayed. Do you manufacture such a product or something equivalent? As a result of my own research I believe that restoring and maintaining the bodys collagen is a very important factor in preventing or minimizing certain diseases. What would you recommend to maintain the bodys collagen? Thanks.

Dear Dr. Dean

I have a question about your Neuroendocrine Theory of Aging specifically Part 6 in the May 2000 issue of Vitamin Research News. On page one you state that loss of sensitivity by the hypothalamus ... enables us to grow & develop. Where does this fit into the subject of aging?

Mr. Anderson

Dear Dr. Dean

My father is 62 years old and he has been using Gerovital for 10 years. He is doing extremely well and has no complaint about his health except a little high total cholesterol (230mg/l)and hypertension (with enelapril it is OK.)

What do you think of this product(GH3)?

Should I suggest that he continue or not?

Thank you
CE

Dear Dr. Dean:

I dont know when to take AGEblock: with or without meals because it has carnosine and vitamins.

I take it at the same time as carnitine and glutamine. Can I take carnosine at the same time?

NC

Dear Dr. Dean:

I am a physician now 73 years old. Over the years I have become increasingly interested in antioxidants and related subjects. As a lifelong skeptic I question many of the claims made. Almost two years ago I was diagnosed with diabetes and metformin was prescribed. I had suffered from hypertension since 1979 which was controlled on ACE inhibitors.

Since I started metformin I note what appear to be significant changes in certain external indices of aging. I am not sure if some of those effects may have been due to weight loss--from 150 at 510 to my present 130 or so. In any case the jowls that were beginning to become noticeable have almost completely receded. There were numerous bumps under the skin in my temporal areas--they have almost completely disappeared. My vision which was blurred--probably because of the high blood sugar--has become much sharper. My blood pressure is now so low (frequently a systolic of 80) that I reduced my Cozaar--the latest medicine-- to 25 mg./ day which still maintains low pressures. This could be due to the decrease in insulin resistance secondary to lowered blood sugars.

I am trying to gain some perspective on how much of this effect might reasonably be attributed to metformin. I am now the chief psychiatrist of a large state prison system. Information about aging and maintaing health would be relevant to the operation of an increasingly-expensive court-mandated health program. I have not seen much on the Internet other than your articles on metformin and aging with an appropriate research design. I know that this medication has been in use for decades even though it was only approved in the U.S. about a decade ago. Do you have any additional references concerning the effects of metformin on aging which are supported by research-backed statistics? One has to always be mindful of the extremely important placebo effect. (This effect is particularly important in psychiatry where the costs of the newer psychotropic medications are extremely high.)

I would appreciate any information that you can send. Thank you advance.

LH Thompson M.D.

Dear Dr. Dean:

I take 1 g of Metformin daily in divided doses. I also practice calorie restriction and have a BMI of 18-18.5. My fasting insulin and HgA1C are well below the reference limits. My serum B12 AST ALT and Bilirubin levels are normal. My homocysteine level is borderline normal. In a recent discussion in the sci-life extension forum Dr Steve Harris thought that I was foolish to take Metformin. He wrote They wont tell you that youre close to main type of metformin toxicity which is lactic acidosis. Metformin itself isnt liver-metabolized (though lactate is) so the main thing that triggers Metformin build-up is reduced renal clearance. That can happen on a day you get dehydrated take an NSAID exercise especially hard get infected-- who knows? The other end of the coin is how much stress youre putting on your lactate production and clearance systems which involve your skeletal muscles and your liver and your cardiac and even pulmonary function. As for your renal function it even falls with aging and how close you are to the edge of starting to develop lactic acidois when youre on Metformin is something for which theres no medical test. You get your creatinine levels checked regularly you stay on the lower dose range of the drug cross your fingers and hope. Kind of dumb if youre not treating diabetes. http://groups.google.com/groups?dq=&hl=en&lr=&ie=UTF-8&safe=off&th=e2d5728e60ae672c

What do you think? Am I foolish to take Metformin and practice calorie restriction?

Tom K

Dear Dr. Dean:

I have read that Glucophage lowers testosterone levels in women. Does it have the same effect on men? If so should men on Glucophage consider testosterone replacement therapy? If so what form of therapy would be best: oral transdermal or injection? Thank you!

PM

Dear Dr. Dean

I just read that JAMA has published an article about the dangers of Metformin (Glucophage) which I know you have recommended as one of the most effective life extension substances available.

Does this news about the danger of Metformin change your recommendations? Also what about the use of aminoguanidine or its close relative Goats Rue Extract that is contained in VRPs AGE-Block and Glu-Control?

JE

Dear Dr. Dean

About METFORMIN -- Ive read your Neuroendocrine series of articles and even ordered some Metformin from IAS. But I havent tried it yet because Im scared about SERIOUS side effects (though rare). To my knowledge Ive never had abnormal kidney problems; liver enzymes were elevated (unexplained) about 10 years ago. I dont drink alcohol nor do I smoke. Q1: Is there any way one can ease into Metformin and get any warning signs if lactic acidosis starts building up -- then discontinue usage before having to go to an emergency room? Q2: Can you comment on or give examples of just what kind of or degree of problem involving liver / kidneys would contraindicate Metformin usage (in perhaps an otherwise healthy individual)? Although made by another company I have been using 200 mg 20- hydroecdysterone 3x daily past 2 months with notable results. Possible suggested alternative to Metformin? Many thanks. Ive been a VERY satisfied VRP customer for 2 years!

Dear Dr. Dean:

I just read an article in the June issue of Life Extension magazine about Metformin. The article indicated that its consumption has similiar results on aging as caloric restriction. If you agree with this what doage of your products would be needed to have this effect?

I currently take 6 Glucontrol`s a day and 3 AGEblocks.

Thank You.
JB

Hi Dr. Dean!

First I wanted you to know that the two doctors we have seen at UCLA were impressed with your articles (and the chart showing all the supplements) on mitochondrial dysfunction.

The first tests showed elevated pyruvate levels at rest and they wanted to do some form of muscle stress test but this isnt possible due to my mothers condition. They may do a muscle biopsy.

I read in the Life Extension magazine their company Biomarker is calling Metformin the most important supplement available to slow aging. I know you have been talking about it for many years.

Anyway thanks for your help.

Tom M

Hi

I recently designed a supplement regime using VRPs products and would like to know if you have any suggestions.

I am a 46-year-old male 5 11 195 pounds and in good health. I would like to keep if possible the number of capsules no higher than the current 11 per day. My goal is high antioxidant life extension and overall health maintenance.

Breakfast: DHEA 50 mg Extend one Green tea 200 mg Lipoic Acid 100 mg

Lunch: Vitamin E 300iu Grape seed Extract 100 mg COQ10 (6321) 75mg

Dinner: Essential minerals Green tea 200 mg Lipoic Acid 100 mg

Bedtime: Melatonin 3 mg

FB

Dear Dr. Dean:

The last information I have on Monaco Anti-Aging Conferences is 2001. Is there published info re. conferences since that time? I am especially interested in the subjects/research/conclusions presented by professionals along with their credentials. Really appreciate any info you have available on the subject, or any references you can provide. Thank you so much.
CD, Research assistant and VRP long time customer.

Dear Dr. Dean

When I was in Mexico years ago I met the late Dr Carl Pilsner (see enclosed literature). I bought some bottles of Minasul from him. I found that I really loved the taste of the sulfur water. When I tried to contact Dr. Pilsner his wife MaryAnne told me that he had died recently. So I never found anyone to answer my questions. I really wanted to find out how healthful it was to drink Minasul and how much he would recommend a day. I am not a water person I dont even drink with meals and this would be a way for me to enjoy drinking glasses of water.

So I wonder if you would be so kind as to give me your opinion if you think Minasul is as healthy as MSM and how many drops per glass and glasses per day you would recommend.

I am 82 years old and I am in very good health. I ski (downhill) in the winter and usually bicycle in Europe Speedhosted in the summer. I attribute my good health to the fact that I eat organically as much as possible and have been drinking raw milk for 40 years. I am not a vegetarian.

I am watching Vitamin Research News very carefully for suggestions.

I had a bone density test in August 2001. It showed slight signs of osteoporosis. In the past 3 months I have been very unsteady on uneven ground and now for the first time I reach for the bannisters on stairs. I have begun to notice that most older people tend to have this problem much earlier than I sometimes in their late 60s.

Sincerely
H. Heyer

Dr. Dean:

I read with interest your Part I of the Neuroendocrine Theory of Aging in the VRP News. I have read a bit about it before but have not studied it extensively. However I should point out that while it perhaps offers the key to the process of maturation it does not fully explain the deterioration present in aging. As human beings we tend to simplify things which are not so simple and I think this is one instance of that. So we should be sensitive to where other explanations fit better.

For example aging deterioration in the bodys glucose transport system seems to follow a different model. Here the evidence seems pretty clear although I know of no single fully controlled study which proves what I am going to say here.

In brief insulin is required to transport glucose across the cell barrier. However the more insulin is present in the bloodstream over time the more its effectiveness in transporting glucose across the cell barrier declines.

Longevity appears to generally be associated with those who minimize their use of insulin. This has been well demonstrated in controlled experiments with lab animals. Those who overuse their insulin (through frequent eating of high carbohydrate foods which stimulate insulin production) develop obesity and type II diabetes. Furthermore type II diabetes is characterized by the cells developing a resistance to insulin so ever-increasing amounts of it are created by the body in a losing battle to have it do its job.

Thus while insulin indeed exists to perform a specific task the more it is called upon to do this task the more it loses the ability to do it in the future. This decline appears basically to be follow a simple paradigm the more you use it the more you lose it.

In a related manner as Dr. Edward Howell pointed out in his studies of the role of digestive enzymes in the 1940s and 1980s the pancreas appears to have a finite capability of enzyme production. After it has used up its production potential then it fails. This is also similar to the heart where again lab studies of animals have shown that animals with slower heart beats live longer than those with faster ones.

In short these illustrate a different model of deterioration in which there is a finite amount of capacity available. Deterioration is defined as usage of this capability over time and longevity depends on using it up slowly. This model complements the Neuroendocrine Theory and certainly in no way competes against it.

Sincerely

Robert

Dear Dr. Dean:

I purchased audio tape series of the Monaco Antii-Aging conference.Several of the participants said that they take Aminoguanidine Dexedrine and Piracetam.

I have not been able to find these products listed anywhere.

Can you tell me what they are and where they can be obtained?

Thank you.
JL

Dear Dr. Dean,
 
In response to the recent article regarding DMAE, I'd like to share my experience.

I began supplementing with DMAE after reading previous VRP articles.  However, I now notice a surface film on my urine that occurs only after taking DMAE.  I no longer supplement with DMAE. 
 
Subsequently, I found research indicating that DMAE significantly inhibits betaine production in the kidney, and suggesting that betaine is an important regulatory kidney solute (see this link: http://physrev.physiology.org/cgi/content/abstract/78/1/247).  As you know, betaine also facilitates homocysteine metabolism, liver functioning, and so on. 
 
This study presumably suggests that DMAE reduces the lifespan of quail:  J Gerontol. 1977 Jan;32(1):38-45. Effects of dimethylaminoethanol upon life-span and behavior of aged Japanese quail. Cherkin A, Exkardt MJ.
 
Furthermore, this study presumably suggests that DMAE is associated with a mild increase in blood pressure:  Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry. Jul1981;138(7):970-2.
 
Are these causes for concern unfounded?
 
Thanks,
 
Mr. D

Dear Dr. Dean

I read that Acetyl-L-Carnitine and (R) Alpha Lipoic Acid when taken together enhances the effectiveness of anti-aging. I am taking both.

However the directions for taking ALC is on an empty stomach while ALA is to be taken with meals. How do I reconcile this?

Sincerely
RY

Dear Dr. Dean:

I read the last two articles on RNA. Would a 27 year old benefit from using it? Also I have a 7-year-old Chihuahua that I would like to give some to. Where can I find out more info on that?

Thanks.

DT

Dr. Dean

I ordered the RNA after reading the last article in the newsletter. The chijuajua dog took 4 grams daily at a weight of about 8 lbs. The recommended dosage on VRPs bottle is l.5 grams daily for a 180 lb male like myself.

Why not recommend a proportionate dosage for humans like 88 grams daily? How did VRP arrive at the recommended dosage? Is there some rational approximation of an appropriate dose? Based on what data?

Thanks

Craig Castanet D.C.

Dear Dr

You told me to take RNA caps three caps TDS. I am on my last bottle and would like to ask you how I should take the powder as I have six bottles of that. (In terms of teaspoons or tablespoons)

Thanks

HW

Dear Dr. Dean:

The May 13 2002 issue of Scientific American cites a panel of 51 aging researchers who pan antioxidants and hormones. Obviously you disagree.

In terms a layman can understand what is the clear and compelling basis for disagreeing with their article? (I am aware that thousands of studies support supplementation. The article claims these have been misunderstood or misrepresented.)

Also if in your view the panel is misrepresenting the evidence your speculations as to why would be welcome.

Thanks.

JK

Dr. Dean:

I have not seen any references to the use of Eldepryl (Selegiline) in your Vitamin Research News for quite a while now. Do you still feel as positive about its use as you did back in 1997? Thank you.

BH

Dear Dr. Dean,

I'm a nurse writing up a research study. And after reading several articles of yours, and others that reference "The Neuroendocrine Theory of Aging," I would like to reference this book as well. I had fully intended to purchase this text, but it appears to be out of print.

One author, (Sandlow) published in the newsletter of the American Academy of Pain Management, makes the following comment:

"Dilman and Dean (1992), who are responsible for the neuroendocrine theory of aging, refer to this as adrenal maladaptation or hyperadaptosis. Hyperadaptosis is considered by some to be a precursor to Cushing's syndrome, and is characterized by prolonged exposure to excess cortisol levels and is caused by the loss of hypothalamic sensitivity to the inhibitory effect of cortisol. (Dilman, 1981)."

It is unclear to me if the comment regarding hyperadaptosis-as-a-precursor-to-Cushing's is attributed to your text, or to Dilman's work: The Law of Deviation of Homeostasis in Diseases of Aging (1981).

I am wondering if you are able to clarify the source of this statement as I would very much like to reference the source. If it is from your work, I'm wondering if you would be willing to look up the page number of this comment. (The journal to which I wish to submit requires page numbers.)

I'm thinking a peek in the index, under Cushing's syndrome or adrenal/pituitary tumor, might locate a page number? Or perhaps the comment is located in a section discussing adrenal exhaustion?

Thank you very much for your time and consideration, Dr. Dean. I realize that this is a completely presumptuous request, but any help would be greatly appreciated.

Regards,
Ms. L RN

Dear Dr. Dean

First why do you not sell TMG and what are your views on this product?

Also why do you only make 50 mg capsules of carnosine?

Please keep up your great work.

Thanks

M. Norton

Dear Dr. Dean:
I recently purchased some AgeBlock the active ingredeint of which is a standardized extract from goats rue. I just found out however that goats rue is a prolactin stimulant. This is not a good thing. Does
AgeBlock use carry this concern?

Steve

Dear Dr. Dean

I read with interest in your VR news regarding glycation + glycosylation occuring when a sugar reacts with a primary amino group; and how the process progresses to form AGES.

Does this process occur when ingesting any carbohydrate such as bread pasta rice etc.? Also finally and most important does this process occur
with Xylitol crystals?

Yours Truly
F. Capps