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Garcinia Cambogia Studied for Possible Effects in IBD and Ulcerative Colitis

By VRP Staff

A new study suggests that garcinia cambogia extract, known for its weight-loss effects, also can reduce the damage that occurs in ulcerative colitis.

Garcinia Cambogia

Inflammatory bowel disease (IBD) and ulcerative colitis are thought to result from a disrupted mucosal immune response. These conditions are characterized by oxidative stress and up-regulation of pro-inflammatory substances. In past studies, garcinia cambogia extract has attracted interest due to its ability to protect the gastrointestinal tract.

In the current study, the anti-inflammatory activity of a garcinia cambogia extract was assessed in experimental colitis in rats. The results obtained revealed that garcinia cambogia administration to colitic rats significantly improved the damage in the intestine and substantially reduced inflammatory markers such as the COX-2 enzyme.  The researchers believe the anti-inflammatory actions were related to the reduction in DNA damage in colon cells noted during the experiment.

According to the study authors, “The anti-inflammatory effects provided by the garcinia cambogia extract result in an improvement of several parameters analyzed in experimental colitis and could provide a source for the search for new anti-inflammatory compounds useful in IBD treatment.”

Dos Reis SB, de Oliveira CC, Acedo SC, da Conceição Miranda DD, Ribeiro ML, Pedrazzoli J Jr, Gambero. Attenuation of colitis injury in rats using Garcinia Cambogia extract. A. Phytother Res. 2008 Oct 31. Published online ahead of print.