Neurochemical Imbalances

Dear Dr. Dean,I have abused several psychoactive substances in the past and as a result, large neurochemical imbalances have effectively impaired my memory, learning ability, focus/concentration and overall awareness. I usually feel hypnotized and like a zombie and my emotions are usually disconnected from me being aware.I have been on antidepressants in the past and my condition is much better now, but still far from where I was before my usage. Can you offer advice about neuro-supplements, neurotransmitter precursors, or anything that could help? Any feedback would be greatly appreciated. Thanks in advance!Mr. L.

Dear Mr. L.,Of course, knowing which neurotransmitter system is impaired would be helpful. Knowing which antidepressant resulted in your greatest improvement would also help.The best combination cognitive enhancer is Extension IQ, which boosts acetylcholine and the dopaminergic neurotransmitters. On the other hand, if you were helped by an SSRI antidepressant like Prozac®, Paxil®, or Zoloft®, I suggest adding 5-HTP or L-Tryptophan, as well. Another suggestion is to try Lithium Orotate. I would try these supplements one at a time, to see what works best for you.Another substance that may help is L-deprenyl. Deprenyl acts by restoring domaminergic receptor sensitivity. In case it is the dopaminergic system that has been “burned out,” this substance may also be of benefit.Let me know how you do.Ward Dean, M.D.